Refining the characterization of residual function in hypertrophic cardiomyopathy through remote segment 4D strain analysis

Background Quantitative assessment of late gadolinium enhancement (LGE) by cardiovascular magnetic resonance imaging (CMR) has been associated with an increased risk of sudden cardiac death (SCD) in patients with hypertrophic cardiomyopathy (HCM). However, patients with lesser degrees of LGE may still remain at high risk of adverse cardiac events due to the diffuse pathophysiology of HCM. Non-invasive characterization of the degree of biomechanical strain within non-enhanced myocardium may be a novel marker of disease in patients with HCM.